Friday, July 1, 2016

Cellular Ageing


DELAY AGING AT THE CELLULAR LEVEL
Every day, the cells in your body are replicating. This process is similar to how a single egg develops into a human being.  It is constantly occurring to renew your skin, hair, blood cells, and some internal organs.

ON-GOING CELL REPLICATION
A cell replicates in two phases. During its first step, interphase, the cell 
gathers nutrients and begins to duplicate the DNA inside its nucleus. Then the cell splits into two, the mitosis phase. This very process is how you grow as a child. Even when we’re fully developed, cells continue to split. However, by the time we’re adults, our cells begin to show some wear and tear.
It’s sort of like using a copy machine. Your first copy of the original is sharp and clear. But if you continue to copy what comes out of the machine, the original image begins to deteriorate. The same principle applies to the DNA in our cells.

THE ROLE OF TELOMERES
​The ends of DNA strands are called “telomeres.” These telomeres are like protective caps on our genes, containing the essential chromosome information inside. Each time a cell replicates, a portion of the telomere wears away. This shortened telomere is duplicated during the next cell division, and becomes shorter again. Once a telomere has effectively worn away, the cell has reached “old age” and loses its ability to divide.

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 On October 7, 3 scientists won the 2015 Nobel Prize in chemistry for their studies of DNA repair. They identified the molecular repair kits. Cells use these to fix damaged DNA. The 2015 Nobel Prize in chemistry was awarded to Tomas Lindahl (left), Aziz Sancar (center) and Paul Modrich (right) for their work on DNA repair.



On October 7, 2015 three scientists won the 2015 Nobel Prize in chemistry for their studies of DNA repair. They identified the molecular repair kits.
Cells use these to fix damaged DNA.Tomas Lindahl is a researcher at the Francis Crick Institute in Potters Bar, England.

Paul Modrich is a Howard Hughes Medical Institute investigator at Duke University School of Medicine in Durham,

​N.C. Aziz Sancar works at the University of North Carolina School of Medicine in Chapel Hill. The trio uncovered three tools for correcting errors in the genetic blueprints of living cells.





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