Extending Life and Fighting Disease with Resveratrol

Scientists are discovering significant additional benefits that resveratrol confers in fighting aging and degenerative disease.1

While much of this research was initiated by a prolific group at Harvard University and in the biotech industry, scientists around the globe are now making unprecedented discoveries that define resveratrol’s multiple preventive and therapeutic potentials.

Most exciting are findings showing how resveratrol may help protect against devastating age-related diseases including cancer, diabetes, atherosclerosis, and Alzheimer’s.

We’ll start with an in-depth look at just what they’re discovering and then review the most compelling findings about resveratrol’s current and future roles in sustaining human health and prolonging life span.

Sirtuins: Inducing the Benefits of Caloric Restriction

At the forefront of the cutting-edge investigations into resveratrol and health and longevity are Drs. Christoph Westphal and David Sinclair.

Christoph Westphal, MD, PhD, has been referred to by Fortune Magazine as “dreamer-in-chief” of biotech startup company Sirtris™ Pharmaceuticals based near Harvard University in Cambridge, MA.2 The moniker is well-earned; Westphal’s dreams appear to include the application of some very exciting science toward the goal of life extension by utilizing resveratrol.

Westphal’s work builds on (and incorporates) that of Harvard scientist David Sinclair, PhD, whose research group is pursuing connections buried deep within the cells of every animal on the planet, that of caloric restriction and longevity. Thanks to the work of Westphal and Sinclair, it is becoming clear that resveratrol mimics the life-span-prolonging effects of caloric restriction, even in animals fed normal or high-fat diets.3-6

It has been known for over 70 years that a drastic reduction in caloric intake slows the pace of aging and increases maximum life span in many so-called “lower organisms” such as yeast, simple worms, and fruit flies;7 more recently, this form of drastic dieting has been shown to have similar effects in mammals.8,9 For years, scientists had no notion of just how caloric restriction worked to prolong life. In 2005, however, Sinclair brought together what was then known about this phenomenon to suggest a new hypothesis, namely that this effect is “an active, highly conserved stress response that evolved early in history to increase an organism’s chance of surviving adversity”8 (scientists use the term “conserved” to describe a characteristic that remains present in organisms over tremendously long periods of time, indicating that it is fundamental to survival of life itself).

The specific molecules that were being conserved turn out to be members of a protein family called the sirtuins (for silent information regulators), which are activated by caloric restriction.10 Like a combination of cellular police, fire, and ambulance services, sirtuins exert myriad effects aimed at preserving intra-cellular civilization—they stabilize chromosomes and DNA molecules, preventing breaks and damage that can lead to cancer, they promote DNA repair, and they regulate genetic functions that in turn control every activity in the living cell.10-12 Most remarkably, decreased sirtuin activity seems to be intimately connected with the cell, tissue, and organ changes that typically occur with aging and that lead to many of the diseases we label “chronic age-related conditions” such as cancer, diabetes, cardiovascular diseases, and neurodegenerative disorders such as Alzheimer’s disease.4,12-16 In fact, Sinclair’s colleague Dohoon Kim recently wrote that sirtuins “constitute a unique molecular link between aging and human neurodegenerative disorders and provide a promising avenue for therapeutic intervention.”17

Resveratrol has the remarkable ability to activate and promote sirtuin activity in virtually all cells, which has been shown to promote the repair and longevity functions that are observed in caloric restriction.6,14,15,18,19 In a stunning demonstration of this effect, a group of Sinclair’s colleagues at the National Institute on Aging fed resveratrol to laboratory mice, producing the same changes in gene expression as those induced by caloric restriction.6Astonishingly, elderly mice fed resveratrol along with a normal diet also showed a dramatic reduction in signs of aging. These reduced markers of aging included decreased protein loss in urine, decreased inflammation, increased elasticity in the aorta, beneficial changes in blood vessel lining cells, greater motor coordination, reduced cataract formation, and preserved bone mineral density! This study, begun when the mice were at mid-life, did not show any increases in longevity—but translated into human terms, these mice would have enjoyed dramatic improvements in the quality of their lives.

Pathologists collaborating with Dr. Sinclair at Harvard have demonstrated increased survival of mice on a high-calorie diet when supplemented with resveratrol, further elucidating the benefits of sirtuin activation.3 This group provided a group of middle-aged mice with a high-calorie diet plus resveratrol, and examined a host of physiological parameters that are affected by age, diet, and obesity. The supplemented mice underwent changes associated with increase in life span, including increased insulin sensitivity, increased numbers of mitochondria in cells, and improved motor function. In fact, the researchers discovered that resveratrol reversed the effects of the high-calorie diet in 144 out of 153 biochemical pathways! Their conclusion was that “these data show that improving general health in mammals using small molecules [such as resveratrol] is an attainable goal, and point to new approaches for treating obesity-related disorders and diseases of ageing.”

We can now review some of the impressive evidence of resveratrol’s health benefits in the context of Sinclair and Westphal’s foundational work on longevity. What is not clear yet is just how many of these benefits relate directly to resveratrol’s effect on sirtuins and how many are tied to its antioxidant and inflammation-fighting activities. Regardless, the following studies offer stunning affirmation of the importance of resveratrol in the quest for longer and healthier lives.

Cardiovascular Benefits

In laboratories around the world, innovative studies identified the impact of resveratrol on reducing the risks of heart disease and the damage from strokes.20 Some of these discoveries include the reduction of atherosclerosis, including control of blood vessel diameter and muscle tone, inhibition of oxidative stress, anti-inflammatory effects, inhibition of LDL (low-density lipoprotein) oxidation, and a reduced “stickiness” of platelets leading to a reduction in deadly clot formation.21-25

WHAT YOU NEED TO KNOW: RESVERATROL

The plant-derived polyphenol resveratrol probably accounts for many of the beneficial effects of the “French Paradox” in whichhigh-fat diets fail to produce devastating effects when red wine is also consumed. Most of resveratrol’s benefits have traditionally been ascribed to its powerful antioxidant and anti-inflammatory effects. Emerging research now shows that resveratrol also stimulates cells to behave as if they had been exposed to caloric restriction, the most powerful life-extending approach known. Through its action on potent cellular-regulating proteins called sirtuins, resveratrol mimics caloric restriction, stimulating healthy cells to survive and diseased cells to die in an organized fashion. Resveratrol-mediated sirtuin activation is now understood to be responsible for many of the health benefits associated with resveratrol supplementation, including protection from aging-associated disorders like cardio-vascular disease, the metabolic syndrome, neurodegenerative disorders, and cancer. Drug companies are rushing to exploit the new findings about resveratrol by turning it into a drug—but highly active supplements are already available, and existing data are all based on use of the natural product.

The multiple health benefits have led even the conservative US Department of Health and Human Services to recommend moderate wine consumption because of its resveratrol content in its Healthy People 2010 initiative.26

In a unique study seeking more knowledge about the complex interaction of resveratrol and heart disease, Korean scientists demonstrated the relationship between resveratrol, inflammation, and blood lipids, immune cells, and the cells lining arterial walls.27 In this remarkable study, the researchers supplemented atherosclerosis-prone mice with either resveratrol, a prescription lipid-lowering drug called clofibrate, or a control diet. The scientists found that resveratrol-supplemented mice had consistently lower total cholesterol and LDL levels than did control animals. Both the resveratrol and the clofibrate-supplemented animals experienced consistently higher levels of beneficial HDL (high-density lipoprotein) than controls. Importantly, the resveratrol-supplemented group also saw significantly higher levels of a vital enzyme called paraoxonase, which is an HDL-associated protein capable of preventing the LDL oxidation that triggers the inflammatory cascade of atherosclerosis.28 And in a remarkable finding, the activity of the cholesterol-producing enzyme HMG-CoA-reductase (HMGR) was significantly lower in both the resveratrol and the clofibrate group—a noteworthy finding, since reducing HMGR activity is the target of the widely prescribed lipid-lowering medications called statins.

Resveratrol also diminished levels of adhesion molecules in vessels walls that are responsible for promoting plaque and clot formation. Of course, the most exciting finding from this comprehensive study was that resveratrol actually reduced the number of atherosclerotic changes and the amount of fat deposition in and around the arteries in the supplemented animals. These researchers concluded that “these results provide new insight into the anti-atherogenic and cholesterol-lowering properties of resveratrol in mice that were fed a normal diet.”

Animal studies also demonstrate resveratrol’s impressive power to prevent or reverse damage even when a cardiovascular event does occur. For example, chronic hypertension and obesity can contribute to an overgrowth of heart muscle known as cardiac hypertrophy, which in turn is a major contributor to congestive heart failure.29,30Canadian researchers showed that resveratrol could reduce rat cardiac cell hypertrophy by blocking inflammatory signals.31 Further, Korean scientists used resveratrol to protect heart cells from free radical-induced cell death.32 And Chinese cardiologists were able to use resveratrol to prevent death of rat cardiac cells through the activation of sirtuins, preventing the subsequent remodeling of heart muscle that contributes to congestive heart failure following a heart attack.33 Similar results are now being obtained in laboratories around the world.34,35

Stroke is another devastating outcome of atherosclerosis, and one that is also ripe for prevention by resveratrol’s multiple modes of action.36 Through its activation of sirtuin molecules, resveratrol can prevent injury to brain cells subjected to stroke-like conditions in the laboratory.37,38 Chinese neuroscientists found that when resveratrol was given to live animals for seven days before an experimentally induced stroke, it reduced the amount of brain tissue injured, while limiting the actual neurological deficits the stroke produced.39 These changes were accompanied by a substantial reduction in the inflammatory markers that are among the hallmarks of brain injury in stroke. Similar results, with the additional benefit of reduction in markers of brain cell oxidation, have been reported by others.40,41Studies with humans and human tissues have also been promising.

A dramatic finding comes from the work of Turkish cardiac surgeons who applied resveratrol to cross-sectional pieces of blood vessels obtained from 38 men undergoing cardiac bypass operations.42 The in-vitro treatment produced relaxations of the vessels of 35%—a dramatic increase in their capacity to carry blood efficiently. They went on to show that these results were directly related to the effects of resveratrol on the vital endothelial layer lining the vessels—the layer that is the most immediate site of atherosclerotic change.

In a 2005 study of 30 men with coronary heart disease, Greek cardiologists examined the effects of a resveratrol-containing red grape extract on flow-mediated dilation (FMD), a sensitive measure of endothelial function in a large artery of the arm.43 Fifteen of the men received the supplement, and 15 a placebo. An ultrasound machine determined FMD after fasting and then at 30-, 60-, and 120-minute intervals following the supplement. Men who took the supplement experienced an increase in FMD significantly above baseline values, peaking at one hour after intake of the supplement, while no change was found in the placebo recipients. Since FMD is a direct measure of arteries’ ability to respond to changes in blood flow, this study provided powerful evidence for a benefit of resveratrol-containing red grape extract on arterial performance.

Another manifestation of resveratrol’s cardiovascular benefit comes from the work of internists in Italy, who were interested in platelet aggregation (clumping), an important part of both atherosclerosis and acute clot formation in heart attacks and stroke.24 This study examined blood parameters from healthy volunteers before and after 15 days of controlled red or white wine intake. The researchers found that wine intake increased the production of the biochemical signaling molecule nitric oxide, blunting a pathological response that ultimately increases platelet aggregation. The scientists pursued the effect further, treating platelets directly with resveratrol at the concentrations they had measured in subjects’ blood. In addition to a number of beneficial effects on nitric oxide production, the researchers also identified reductions in the activity of inflammatory pathways and systems that produce destructive reactive oxygen species.

Diabetes and the Metabolic Syndrome

Type 2 diabetes is associated with development of the metabolic syndrome, which dramatically elevates risk of cardiovascular disease, the number one cause of death in the aging population.16,44 Epidemiologic studies have established beyond doubt that red wine consumption is associated with a lower incidence of metabolic syndrome and heart disease, and scientists believe the resveratrol component may explain why red wine is more effective than alcohol in general.44 According to Dr. Ling Liu of the University of Hong Kong, “[resveratrol] can act as a potent activator of … sirtuins to expand the life span and to prevent the deleterious effects of excess intake on insulin resistance and metabolic derangement.”44 In fact, resveratrol’s activation of sirtuins is so effective that many researchers are now interested in its use as a potential drug for the treatment of diabetes.45 Let’s examine in more detail a few of the landmark studies of resveratrol’s metabolic effects.

Since cellular uptake of glucose is impaired in diabetes, Canadian researchers decided to examine the effects of resveratrol on enhancing muscle cells’ ability to absorb sugar—an insulin-like function.46 In a laboratory culture of skeletal muscle, the researchers found that addition of resveratrol stimulated glucose uptake to more than 200% of baseline, similar to the action of insulin itself. They were able to trace this effect to the stimulation of sirtuins in the muscle cells. Such activity in humans has the potential to help regulate glucose levels in the blood of diabetic patients, while enhancing delivery of much-needed glucose to hungry skeletal muscles. Of interest is that a similar improvement in insulin-glucose function occurs in response to calorie restriction.

Taking resveratrol treatment a logical step further, Spanish researchers in the Basque country explored the effects of resveratrol on prevention of non-alcoholic fatty liver disease in laboratory rats.47 This is a crucial area of research because non-alcoholic fatty liver disease is linked to obesity, diabetes, and elevated triglyceride levels in blood—all independent risk factors for cardiovascular disease. The researchers fed rats either a control diet or a high-carbohydrate diet for four weeks, including resveratrol in one group of the high-carbohydrate subjects. As expected, the high-carbohydrate group developed fatty liver and associated inflammatory biochemical changes seen in humans. The resveratrol group had decreased fat deposition in their livers compared with the untreated high-carbohydrate group, and also had significant reductions in levels of inflammatory and oxidative stress markers in their blood. The supplemented animals also had higher levels of natural antioxidant enzymes that help combat the effects of oxidized fat molecules. Finally, glucose levels were decreased in the resveratrol-supplemented group.

In a remarkable set of studies, biochemists in Madras reported on a direct comparison of resveratrol with an oral glucose-lowering drug, glyclazide, in control of blood sugar levels in diabetic rats.48,49 The animals were treated with resveratrol orally for 30 days, and experienced a significant decrease in blood sugar, the target outcome. Of clinical importance, the animals also had significant reductions in levels of hemoglobin A1C, a sensitive marker of long-term sugar levels and of protein damage caused by exposure to elevated sugars. The animals were also found to have lower levels of biomarkers of inflammation and liver injury. The researchers noted that these effects are comparable with those of glyclazide, and concluded that “resveratrol may be considered as an effective therapeutic agent for the treatment of diabetes mellitus.”49

Another group of Spanish investigators studied obese rats in a model of the metabolic syndrome.50 These animals, like their human counterparts, have high plasma lipid (fat) levels, insulin resistance, and increased levels of inflammatory molecules produced in their abdominal fat—all destructive changes we know to be associated with cardiovascular disease and other metabolic syndrome consequences. Amazingly, all of these metabolic disruptions were significantly reduced when the animals received resveratrol supplementation. Interestingly, and significantly for overweight and obese humans, the supplemented animals also had reductions in their blood pressure. Encouragingly, resveratrol mimics many of the metabolic benefits of caloric restriction through its activation of sirtuins, without the deprivation associated with a reduced calorie diet.51

Neurodegenerative Diseases According to the noted Spanish neuropharmacologist Merce Pallas, “healthy aging remains one of the ideals of modern society.”52 Nowhere are the ravages of unhealthy aging more visible than in the terribly destructive neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases—and because these diseases are linked inexorably to oxidative damage and inflammation, resveratrol researchers hold high hopes for the molecule’s potential impact in these areas. It has been suggested that, like caloric restriction, resveratrol helps to preserve and regulate energy levels in brain and nerve cells, prolonging their active lives in part through beneficial, sirtuin-activating effects on mitochondria, the cellular powerhouses.41,53-56 Direct evidence of a resveratrol-mediated neuroprotective effect in Alzheimer’s disease was published in 2009 in a report by Cornell neuroscientists who studied mice given an experimental version of human Alzheimer’s.57 The mice were given resveratrol over a 45-day period; their brains were then examined for the damaging inflammatory beta-amyloid plaques characteristic of Alzheimer’s disease. Despite finding no resveratrol directly in the brain tissue, the scientists reported reductions in plaque formation of 48% to 90% in specific and important regions of the brain! These dramatic changes were accompanied by substantial increases in brain antioxidant molecules. The researchers concluded that “onset of neurodegenerative disease may be delayed or mitigated with use of dietary chemopreventive agents that protect against beta-amyloid plaque formation and oxidative stress.” It’s not just in chronic degenerative diseases of the brain that resveratrol holds promise—neurosurgeons in Turkey found that resveratrol actually produced better biochemical outcomes in an animal model of spinal cord injury than did methylprednisolone, the steroid commonly given in high doses to trauma victims.58 And the mitochondria-preserving characteristics of resveratrol are now being explored by other neurologists and neurosurgeons as a means of preventing the devastating neurotoxic effects of restoring blood flow to brain tissue deprived of oxygen.41 RESVERATROL MAY REVERSE ARTERIAL AGING Click To View “Atherosclerosis is reversible” is not a phrase we expected to hear from mainstream medical researchers until very recently—since these are the precise opening words of a remarkable editorial about resveratrol that appeared in a recent issue of the prestigious New England Journal of Medicine.67 Just as astonishingly, the editorial was written by a renowned immunologist, Linda K. Curtiss, PhD, of the Scripps Research Institute in La Jolla, California. The fact that an immunologist is writing about cardiovascular disease in a trend-setting medical journal speaks volumes about how far we have come in our understanding of chronic diseases and their relationships with inflammation, which is an immune system phenomenon. What truly sets Dr. Curtiss’s article apart, though, is her description of a dramatic new phenomenon mediated by the grape polyphenol resveratrol. Curtiss’s excitement comes from work done by Cleveland Clinic cell biologist Young-Mi Park, MD, who was exploring the role of oxidant stress and inflammation on the pathogenesis, or disease-causing mechanisms, of atherosclerosis.68 Knowing that fat-laden inflammatory cells called foam-cell macrophages trigger inflammation when they become trapped beneath the lining of blood vessels,69-72 Park’s team sought to understand why the cells become trapped, and how they could be freed from their “endothelial bondage,” thereby reversing the inflammatory process. The most natural approach to take, Park’s group decided, was simply to test known antioxidants’ ability to prevent the foam cells from migrating into the endothelial lining in the first place, and their ability to release any cells that were already present.68 Specifically, they studied how oxidized low-density lipoprotein (LDL) promotes foam-cell formation and impairs migration. To do this they blocked LDL oxidation with several potent antioxidants. They found that oxidized LDL actually triggered production of a sort of cellular “glue” in the form of filaments of actin, one of the proteins also found in muscle tissue. The actin filaments were entangling the foam cells, preventing their natural migration out of the endothelial lining, leading to progressive inflammatory changes. Park’s group chose resveratrol as one of the two antioxidants to test—another testimony to the respect that mainstream researchers are according this remarkable molecule (the other was N-acetylcysteine, also an antioxidant available in supplement form).68 Resveratrol treatment of the foam cells inhibited production of reactive oxygen species by greater than 90%, an important first step in breaking the cycle. Even more impressively, resveratrol partially restored the foam cells’ ability to move out of the entangling actin filaments, and migrate away from the endothelial lining! This brings us back to Dr. Curtiss’s astounding initial observation that atherosclerosis is a reversible condition—through the use of powerful antioxidants such as resveratrol, we can now understand how oxidized LDL contributes to invasion of endothelium by inflammatory cells, and how prevention or reversal of LDL oxidation promotes mobilization of inflammatory cells and their emigration away from vessel linings. As Dr. Park concluded, “[these studies] also provide additional mechanistic support for the atheroprotective effect of antioxidants.”68 Resveratrol is already well-known as a cardiovascular protective supplement—the work of Park and others is now showing us that resveratrol must also be considered a valuable cardiovascular therapeuticsupplement, one that can literally “turn back the clock” on chronic vascular diseases of aging! Cancer Cancer is one of the most-feared scourges of humanity, and the risk of cancer increases progressively with advancing age. It is only in the past three years that significant attention has been paid by oncologists to the chemopreventive capacity of resveratrol—but that omission is being rapidly remedied through an outpouring of new research. Roman biologists have discovered, for example, that the most active form of the molecule, trans-resveratrol, causes human breast cancer cells in culture to commit the orderly suicide referred to as apoptosis, one of the most important and effective means of treating cancers and of preventing their progression.59 Scientists at the University of Nebraska Medical Center even found that they could utilize resveratrol to prevent damage to DNA caused by excess estrogen, effectively preventing the initiation of some breast cancers.60 Because resveratrol acts by so many different mechanisms, it represents a true “multiple-prong” approach to prevention and treatment of cancers. These effects are especially notable in tissues with a high rate of natural cell turnover, where carcinogens can rapidly corrupt the DNA code and induce tumors—tissues such as the gastrointestinal tract and the skin. Oncologists at the Northeastern Ohio Universities Colleges of Medicine and Pharmacy in Ohio, for example, found that they could use resveratrol to inhibit liver cancer cells from proliferating, and cause them to undergo death by apoptosis, ultimately reducing the size and number of liver tumors in rats given a potent carcinogen.61 A more profound understanding of resveratrol’s role in toxin-induced cancers (typical of the gastrointestinal tract and skin) has been revealed just this year, by Italian toxicologists studying the powerful enzyme systems involved in carcinogenesis.62 Remarkably, they have demonstrated that resveratrol inhibits the actions of certain “bioactivating” enzymes that inadvertently convert minor toxins into major carcinogens, and at the same time promotes activity of detoxifying enzymes that help prevent conversion of normal cells into cancerous tumors. Indian toxicology experts also found that resveratrol prevented cancerous changes—this time in a rat model of skin cancer.63 Using resveratrol, they could delay the onset of tumor development, reduce the total number of tumors, and reduce tumor size in the skin of rats treated with a potent carcinogen. The scientists concluded that resveratrol regulates apoptosis and cell survival in mouse skin tumors and deserves consideration as a potent chemopreventive agent. Finally, also early in 2009, another group of Indian scientists reported that they could block toxin-induced colon cancers in rats by supplementing them with resveratrol before exposing them to a deadly carcinogen.64 Like the preceding group, they found reductions in both the occurrence rate and the size of tumors; importantly, both benign and malignant tumor types were suppressed. Though we are midway through 2009, a host of other new studies have already appeared, confirming and extending findings about resveratrol’s astonishing chemopreventive capabilities.41,65 Summary The plant-derived polyphenol resveratrol, and especially its highly active form, trans-resveratrol,5,59,66 have been making big news in recent days. We’ve long known that resveratrol has potent antioxidant and anti-inflammatory effects, making it a key item in our armamentarium of supplements that can prevent age-associated chronic illness. The real news is that resveratrol continues to be linked to the life-extending effects of the powerful sirtuin molecules that control the fundamental processes associated with aging itself. By potently activating sirtuins, resveratrol stabilizes DNA to prevent cancerous changes, switches on antioxidant and anti-inflammatory defense mechanisms native to cells, and even instructs certain cells to commit organized suicide by apoptosis. The end result is an almost incredible array of health benefits, from reduction in cardiovascular risk factors to protection against neurodegenerative disease to cancer prevention. Indeed, resveratrol is being actively explored now by big pharmaceutical companies eager to cash in on its potency by creating new drugs derived from the natural molecule. But there’s no need to wait, because highly purified forms of trans-resveratrol are already available, waiting to provide their beneficial effects immediately. If you have any questions on the scientific content of this article, please call a Life Extension Health Advisor at 1-800-226-2370.

References

1. Pathophysiol Haemost Thromb. 2003 Sep 20;33(5-6):466-71. 2. Fortune. 2007 Jan 9. 3. Nature. 2006 Nov 16;444(7117):337-42. 4. Neurochem Res. 2008 Dec;33(12):2444-71. 5. Curr Med Chem. 2008;15(19):1887-98. 6. Cell Metab. 2008 Aug;8(2):157-68. 7. Methods Mol Biol. 2007;371:97-109. 8. Mech Ageing Dev. 2005 Sep;126(9):987-1002. 9. Metab Syndr Relat Disord. 2008 Oct 18. 10. Biochem J. 2007 May 15;404(1):1-13. 11. PLoS ONE. 2008;3(4):e2020. 12. Trends Biochem Sci. 2007 Jan;32(1):1-4. 13. Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2721-35. 14. Nature. 2003 Sep 11;425(6954):191-6. 15. PLoS Biol. 2007 Oct 2;5(10):e261. 16. Genes Nutr. 2006 Jun;1(2):85-93. 17. EMBO J. 2007 Jul 11;26(13):3169-79. 18. Nature. 2007 Nov 29;450(7170):712-6. 19. Nature. 2004 Aug 5;430(7000):686-9. 20. Arch Mal Coeur Vaiss. 2006 Dec;99(12):1230-5. 21. J Med Food. 2008 Dec;11(4):610-4. 22. J Pharmacol Sci. 2008 Sep;108(1):124-30. 23. Nutr Metab (Lond). 2008;517. 24. J Nutr. 2008 Sep;138(9):1602-8. 25. Nutr Res. 2008 Nov;28(11):729-37. 26. Exp Clin Cardiol. 2006;11(3):217-25. 27. Biochem Biophys Res Commun. 2008 Sep 12;374(1):55-9. 28. Arterioscler Thromb Vasc Biol. 2001 Apr;21(4):542-7. 29. Curr Vasc Pharmacol. 2008 Oct;6(4):292-300. 30. Drugs Today (Barc). 2008 Jul;44(7):503-13. 31. J Biol Chem. 2008 Aug 29;283(35):24194-201. 32. Genes Nutr. 2008 Feb;2(4):323-6. 33. Biochem Biophys Res Commun. 2009 Jan 16;378(3):389-93. 34. Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2138-43. 35. Arch Biochem Biophys. 2007 Jan 1;457(1):1-6. 36. Curr Med Chem. 2008;15(12):1236-48. 37. J Cereb Blood Flow Metab. 2006 Sep;26(9):1141-7. 38. Curr Med Chem. 2008;15(15):1545-51. 39. Zhongguo Zhong Yao Za Zhi. 2007 Sep;32(17):1792-5. 40. J Vasc Surg. 2007 Aug;46(2):346-53. 41. Brain Res. 2009 Jan 23;1250:242-53. 42. Eur J Cardiovasc Prev Rehabil. 2005 Dec;12(6):596-600. 43. Int J Cardiol. 2005 Nov 2;105(2):209-15. 44. Endocr Metab Immune Disord Drug Targets. 2008 Jun;8(2):89-98. 45. Biochem Biophys Res Commun. 2008 Aug 29;373(3):341-4. 46. Biochem Biophys Res Commun. 2008 Sep 12;374(1):117-22. 47. BMC Gastroenterol. 2008;840. 48. Chem Biol Interact. 2008 Nov 19. 49. Biomed Pharmacother. 2008 Nov;62(9):598-605. 50. Biochem Pharmacol. 2009 Mar 15;77(6):1053-63. 51. FASEB J. 2008 Dec 4. 52. Recent Pat CNS Drug Discov. 2008 Jan;3(1):61-9. 53. Proc Natl Acad Sci USA. 2007 Apr 24;104(17):7217-22. 54. Expert Opin Investig Drugs. 2007 Dec;16(12):1921-31. 55. Clin Interv Aging. 2008;3(2):331-9. 56. Med Sci (Paris). 2007 Oct;23(10):840-4. 57. Neurochem Int. 2009 Feb;54(2):111-8. 58. Acta Pharmacol Sin. 2006 Oct;27(10):1317-25. 59. Genes Nutr. 2007 Dec;2(3):295-305. 60. Cancer Prev Res (Phila Pa). 2008 Jul;1(2):135-45. 61. Chem Biol Interact. 2008 Nov 27. 62. Food Chem Toxicol. 2009 Feb;47(2):454-61. 63. Pharm Res. 2009 Jan;26(1):211-7. 64. Phytother Res. 2009 Jan 22. 65. Autophagy. 2009 May 19;5(4). 66. Anal Sci. 2008 Aug;24(8):1019-23. 67. N Engl J Med. 2009 Mar 12;360(11):1144-6. 68. J Clin Invest. 2009 Jan;119(1):136-45. 69. Immunity. 2004 Oct;21(4):561-74. 70. Arterioscler Thromb Vasc Biol. 2002 Feb 1;22(2):211-7. 71. Curr Atheroscler Rep. 2004 Mar;6(2):112-20. 72. Thromb Haemost. 1997 Jul;78(1):200-4.

From : http://www.lifeextension.com/

Resveratrol Found to Halt Growth of Pancreatic Cancer Cells

(NaturalNews) Recent research suggests that the antioxidant resveratrol, which naturally occurs in grape skins, can weaken pancreatic cancer cells and increase their vulnerability to chemotherapy.

"Resveratrol seems to have a therapeutic gain by making tumor cells more sensitive to radiation and making normal tissue less sensitive," said lead researcher Paul Okunieff, chief of radiation oncology at the University of Rochester Medical Center.

In a study published in the journal Advances in Experimental Medicine and Biology,Okunieff and colleagues treated a group of pancreatic cancer cells with 50 mg of resveratrol, then iodized them to simulate the action of chemotherapy. Another group of cancer cells was iodized without undergoing any resveratrol treatment.

Pancreatic cancer has long been known to be particularly resistant to chemotherapy. The researchers discovered that because the pancreas is continually producing digestive enzymes and pumping them into the duodenum, these enzymes actually flush away chemotherapy chemicals before they can have much impact.

But in pancreatic cancer cells that had been treated with resveratrol, the cell membrane proteins responsible for this flushing had their functioning hampered. In addition to becoming more sensitive to chemotherapy, the cells also became more likely to undergo programmed death (apoptosis) due to the increased production of reactive oxygen species.

While the reason for the decreased pumping action was not clear, it may have been a side effect of yet a third observed effect of resveratrol treatment: The mitochondria of the cancer cells was damaged, with its membranes depolarized. Because mitochondria are the energy source of the cell, damaged mitochondria hampers the cell's general ability to function, including its ability to flush out chemotherapy drugs.

As a naturally occurring ingredient of red wine, resveratrol has drawn much attention from researchers investigating whether it might be responsible for wine's well-documented health benefits. Like all antioxidants, resveratrol is known to remove free radicals from the blood. Free radicals are known to be linked with cancer, inflammation related to cardiovascular disease, and the effects of aging.

But scientists are also hard at work uncovering resveratrol's more specific effects. Numerous studies have demonstrated that the chemical can extend the lifespan of simple organisms such as worms and yeast, and even complex animals like fish. In one 2003 study, short-lived fish dosed with resveratrol lived more than 50 percent longer than fish not treated with the antioxidant. In addition, these fish had better swimming and learning ability at the end of their lives than the control fish did.

Other studies have shown that resveratrol protects plants from bacterial or fungal infection and makes HIV more susceptible to certain antiviral drugs. In cells infected with the influenza virus, resveratrol treatment reduced the virus' ability to reproduce by 90 percent over a period of 24 hours.

Resveratrol has also been shown to improve treadmill endurance in mice, and even to neutralize the negative effects of a high-fat diet. Mice fed a high-fat diet supplemented with 22 mg/kg of resveratrol had a 30 percent lower chance of dying when compared with mice eating only an unsupplemented high fat diet. This was approximately the same risk of death as mice eating a normal, non-high-fat diet.

Finally, a number of studies have suggested that the antioxidant has anti-cancer benefits, from preventing the development of skin cancer in mice exposed to ultraviolet radiation to reducing the risk of esophageal or colorectal tumors in mice and rats exposed to carcinogens. It has also been shown to induce apoptosis in human fat cells under certain specific circumstances.

"Antioxidant research is very active and very seductive right now," Okunieff said. "The challenge lies in finding the right concentration and how it works inside the cell."

The highest concentrations of resveratrol are found in grape skins. Peanuts contain about half as much resveratrol as grapes, while blueberries and bilberries contain only about 10 percent as much.

While the resveratrol content of wine varies widely depending on the variety of grape, when and where it was grown, and how long it was fermented, the high level tends to be 30 mg per ml. This is lower than the dose used in the current study. But Okunieff said that higher doses should be safe as long as they are taken under a doctor's supervision.

"While additional studies are needed, this research indicated that resveratrol has a promising future as part of the treatment for cancer," he said.

Approximately 33,000 new cases of pancreatic cancer are diagnosed in the United States every year. Patients have a very low rate of survival, in part due to the disease's resistance to chemotherapy.

source : https://www.naturalnews.com/

GABA-Boosting Brain Foods

While there are several drugs that help to boost GABA, there are also some natural ways to get the peace and calm your brain needs. Finding natural solutions have a few benefits. First, they’re not addictive like many of the prescription medications. Also, they won’t leave you feeling groggy, so you’ll still be able to be productive at work and at home.

You know that feeling you get in the middle of a frantic workday with 3 deadlines approaching while your kids keep texting you about dinner? If we were to take a look inside your brain, the chemicals that act like your car’s accelerator pedal – dopamine, adrenaline, norepinephrine – are surging. And GABA, the chemical that acts like your car’s brakes, is in short supply.

http://www.doctoroz.com/episode/biggest-scams-threatening-your-health

Here are 5 ways to get the GABA your brain is craving:

1. Swap your afternoon coffee for a cup of oolong tea. When we feel overworked and worn out, coffee is a natural go-to. But its high levels of caffeine send the activating brain chemical dopamine soaring. The tradeoff for short-term productivity is a jittery feeling and insomnia hours later. Try oolong tea instead. It contains GABA, and sipping it may provide you with the break your brain and body needs. The break you’ll get may provide you with the stamina to get everything done without feeling worn out.
2. Swap the candy bar for cherry tomatoes and hummus. The high levels of fat in that candy bar are not only bad for your waistline, it’s bad for your brain! High levels of unhealthy fat also increase dopamine levels. But cherry tomatoes are rich in GABA, and the olive oil in hummus helps to balance your omega-3 versus omega-6 ratio. This ratio can help balance all of your brain chemicals over the long-term which will leave you feeling peaceful and happy.
3. Swap the soda for a glass of kefir, a probiotic drink. Soda is not only associated with obesity; a new study showed an association with soda (and diet soda) and depression. Kefir contains GABA, and the carbohydrates boost serotonin – your other main feel-good, peaceful brain chemical. Talk about a double whammy!
4. Swap orange chicken and fried rice for grilled shrimp and brown rice. The high fat in orange chicken and fried rice flood your brain with dopamine which can even set you up for food addiction. But the shrimp contains a healthy dose of GABA, and the high-fiber brown rice gives you nice, healthy release of serotonin.
5. Ditch the TV and downward dog your way to bliss. At the end of a long day, sitting on the couch and mindlessly watching hours of TV may be the easy fix. But if we really want to get the peace and happiness we’re really craving, we may have to get a little more creative. Buy yourself a zafu – a round meditation pillow. When you get home, set the kitchen timer for 10 minutes and practice meditation. Start increasing that time by 1 minute each day until you can sit for 30 minutes. Or, find a great yoga class, and go with friends. Your body and your brain will thank you!

Topic from:  http://www.doctoroz.com/article/gaba-boosting-brain-foods

T.A. Sciences receives US patent for TA-65 to tackle aging process

January 14, 2011

Telomerase Activation Sciences, Inc. (T.A. Sciences) today announced the issuance of U.S. Patent No. 7,846,904 to the Geron Corporation. The patent covers the use of certain compounds to upregulate telomerase expression in cells.

T.A. Sciences has exclusive worldwide rights to technology under this patent for nutraceutical and cosmetic applications.

"This foundational patent is a validation of the millions of dollars and more than 8 years of effort we have invested to bring TA-65, the world's first telomerase activator, to market," stated Noel Thomas Patton, Chairman of T.A. Sciences. "This significantly adds to the proprietary rights that Geron has built around its already strong portfolio of U.S. and foreign patents that will allow vigorous defense against infringers. T.A. Sciences has provided TA-65 to hundreds of clients for nearly four years with significant demonstrated anti-aging and immune boosting benefits."

"Cells are the building blocks for all tissues in the human body and cell division plays a critical role in the normal growth, maintenance and repair of human tissue. We and our collaborators have shown that telomeres, located at the ends of chromosomes, are key genetic elements involved in the regulation of the cellular aging process. Thus, this shortening of the telomeres effectively serves as a molecular 'clock' for cellular aging. We and others have shown that when the enzyme telomerase is introduced into normal cells, it can restore telomere length - reset the 'clock' - thereby increasing the functional lifespan of the cells. Importantly, it does this without altering the cells' biology or causing them to become cancerous...Controlled activation of telomerase in normal cells can restore telomere length or slow the rate of loss, improve functional capacity and increase the proliferative lifespan of cells," Source:Geron 2009 Annual Report.

The awarding of the patent follows the first published peer reviewed scientific paper on TA-65: "A Natural Product Telomerase Activator..." which appeared in the journal Rejuvenation Research in Sept 2010. This study focused on two key results that were observed in T.A. Sciences' clients who had taken TA-65 for a 12 month period. TA-65 led to a reduction in the percentage of short telomeres in immune cells and also showed a significant restoration of the immune system back to a more youthful profile.  A number of other significant improvements were observed in various biomarkers which show decline with age and these will be reported in a subsequent paper. Importantly, there were no reported side effects.

Related Stories

• Research provides new insights into how telomeres regulate cellular senescence
• People with family history of bipolar disorder may 'age' more quickly than others
• Study identifies new susceptibility loci for lung cancer

Two earlier papers help to confirm these benefits.  The first paper (Fauce et al., 2008) describes the chemical structure of a small molecule telomerase activator discovered at the Geron Corporation in collaboration with the Hong Kong University of Science and Technology. They were able to demonstrate that activating telomerase with a telomerase activator slowed the rate of telomere loss, increased replicative capacity (without immortalization or signs of tumor transformation), restored cytokine and chemokine response of cytotoxic CD8 cells exposed to specific antigens. The other, a 2005 Double Blind, Placebo Controlled  Human Trial also demonstrated improvements in immune function, vision, sexual function, and skin elasticity.

Telomere Biology has become the most relevant topic in anti-aging research. In a study released on November 28th 2010, in the online journal Nature, a team of researchers at Harvard Medical School reported on the first reversal of the aging process in a mammal. By reactivating telomerase, they rejuvenated worn out organs in mice that were the equivalent biological age to 80 year old humans. This along with the 2009 Nobel Prize in Medicine being awarded for the discovery of telomerase and the publication of over 8,000 other scientific articles about telomere biology confirm the emergence of a major scientific platform.  

All of this emphasizes the importance of short telomeres in the aging process and has ushered in a new approach to how we tackle aging in humans. That approach is to stop telomere shortening by activating telomerase. And now TA-65 is the first and only product available which has been shown to effectively activate this enzyme.

From：http://www.news-medical.net/news/20110114/TA-Sciences-receives-US-patent-for-TA-65-to-tackle-aging-process.aspx

FINITI ：

main Ingredients: TA-65 MD

Anti-Aging Pill: New Study on TA-65 Sparks Controversy

A major new study claims the pricey supplement TA-65 may turn back the clock, all the way down to our DNA—but many scientists are brushing it off as snake oil. Thea Singer investigates.

In an era of seemingly magical technology, the notion that scientists could develop a pill that might slow the aging process doesn’t seem that far-fetched. After all, we can now perform face transplants. We can control machines with our minds. How far could we be from producing a treatment that rejuvenates our cells?

According to some researchers: We’re already there. For several years now, a handful of supplement and biotechnology companies claim to be hot on the trail of the miracle anti-aging formula humankind has long sought—and one product has already hit the market.

Made from a Chinese herb called Astragalus membranaceus, the “nutraceutical” is referred to by the equally futuristic and drab-sounding name of TA-65. And it claims to reverse the clock at a cellular level, all the way down to our DNA. The capsule ranges from $1,200 to $4,000 for a six-month supply, depending on the dose.

T.A. Sciences, a New York supplement company, manufactures the pill, andemployees swear by it. “My immune system is younger, my eyesight is improved, the glucose and cholesterol levels in my blood have gone down, and I have increased cognitive function,” says Noel Patton, the 65-year-old founder and CEO of the company. He’s been taking it for four years.

The mainstream scientific community has, for the most part, viewed the supplement extremely skeptically. But a new study, backed up by a few scientific heavyweights, suggests that it may just work. The paper appears today in Aging Cell—though the journal was so eager to get the word out that it posted it online in late March, even before the acknowledgments were complete. My quest to investigate the study, however, led to a tangled web of believers and nonbelievers, and a raging controversy in the field of anti-aging research. Is T.A. Sciences marketing snake oil, or a ticket to prolonged youth?

To understand the paper’s implications, it helps to understand how TA-65 claims to work. The pill purports to restore our telomeres—the protective caps at the end of our DNA. Like the plastic tips at the end of shoelaces, these caps, with time, illness, and stress, eventually wear down, leading to physical signs of aging. Scientists now view telomere length as an overall marker of biological aging. For example, babies have longer telomeres than adults—or, as Patton put it to me, in a kind of cognitive foot-in-mouth, “babies are always born young.”

My quest to investigate the study led to a tangled web of believers and nonbelievers—and a raging controversy in the field of anti-aging research.

Over the past few decades, the study of telomeres has risen to become a white-hot area of very legitimate scientific research. In 2009, a team of scientists won the Nobel Prize in Physiology or Medicine for their breakthrough research into how telomeres work. Each time a cell divides, its telomeres get progressively shorter. When telomeres get so short that a cell can’t function, the cell either enters a resting state or dies.

But there’s a rejuvenative source for these worn-out cells. And that’s what T.A. Sciences aims to tap into—along with a California company called Geron Corp., a biotech dedicated to developing drugs to treat cancer and chronic degenerative diseases, which licensed TA-65 to Patton as a neutraceutical while keeping its own extract from the Chinese plant, called TAT2, to develop as a drug.

That life-giving source is the enzyme telomerase, which can actually lengthen telomeres. TA-65, the new study claims, is a “telomerase activator”—that is, it turns on telomerase in cells. Studies suggest that telomerase can also beactivated naturally, through exercise, meditation, and other healthy lifestyle changes. But taking a pill is, of course, easier.

The lead author of the new paper is Maria Blasco, a prolific scientist who heads the Telomeres and Telomerase Group at the Spanish National Cancer Research Centre. In the paper, Blasco reports that in genetically engineered mice, TA-65 rescued cells in jeopardy and improved health without increasing cancer incidence—a risk when cells can divide for longer periods of time.

In her study, a group of middle-aged and old mice ate food spiked with TA-65, while another group, the controls, ate plain food. (The age of the mice was intentional: TA-65 is marketed to people in their forties and up.) After three months, the scientists took blood samples, and measured the lengths of the telomeres of both groups. And sure enough: Mice that ate the TA-65 had a lower percentage of “very short telomeres.” They also displayed lower insulin levels, hair regrowth, and increased skin plumping. Blasco takes these changes as evidence that TA-65 works by “turning on” telomerase.

But the changes didn’t last, and overall longevity didn’t change. Nor did average telomere length of the treated mice—a measure that countless previous studies have deemed the more important measure, as it’s been proven to correlate with everything from reduced disease risk to lower mortality.

This last detail concerns Carol Greider, who, along with Elizabeth Blackburn and Jack Szostak, won the Nobel for the discovery of telomerase and how telomeres protect chromosomes. “There are a number of questions about the actual claims just in terms of: Is TA-65 really doing what they think it’s doing?” says Greider about the new paper.

She reflects, too, on an earlier study, in the journal Rejuvenation Research, showing similar results in humans (that is, T.A. Sciences customers) taking TA-65, along with vitamin supplements: The subjects’ mean telomere length did not increase, but their percentage of very short telomeres appeared to decrease. “I haven’t seen yet that they actually change telomere length, which is the clear real indicator,” adds Greider.

When I first contacted the Nobel laureate, she sent me a paper reporting that if taken in pill form, Geron’s drug-in-progress from the Chinese herb (TAT2) couldn’t even get to the body’s cells to make a difference. “This particular drug wouldn’t be one that you would give orally,” says Greider. “There would need to be some sort of chemical modification… for it to actually be useful.” No one connected to TA-65 will say if the supplement and TAT2 are chemically the same—“it’s a trade secret,” says Patton. But he assured me that results from studies on TAT2 are “definitely applicable” to TA-65.

Calvin Harley, a co-author on all three papers and chief scientific officer of Telome Health Inc., a new telomere-diagnostics company based in Northern California, acknowledges that concentrations of the active anti-aging ingredient may be low. But he says the pill can still activate telomerase in human cells in the lab—and the low potency helps to reduce safety concerns.

But Greider and other scientists point out both Blasco and Harley’s vested interest in the pill. Harley, 58, is a pioneer in telomere research, and a rigorous scientist. But he’s also an inventor of TA-65, and an adviser to both Geron and T.A. Sciences.

“I hate to say it, but I really think that money corrupts,” says noted cellular aging researcher Judith Campisi, pointing to the timing of the paper’s release—which happens to coincide with the launch of Blasco’s new company, Life Lengths, which measures people’s telomeres. Campisi, based at California’s Buck Institute for Research on Aging, has another concern as well: Telomerase doesn’t cause cancer, but cancer cells are telomerase-rich—it’s what enables them to divide indefinitely. Blasco’s new paper reports that the treated mice did show an increase of liver cancer, though those levels “did not reach statistical significance.”

Ultimately, the paper—and the supplement—may prove to be an important step in leading to a formula that, in fact, allows us to live longer, and with a higher quality of life. But for now, as Campisi points out about the splashy new study: “It really reads like an apology for a company.”

Thea Singer has written about health and science for more than three decades. Based in Boston, she is the author of Stress Less (Hudson Street Press/Penguin Group, USA), which reveals how stress ages us down to our DNA, and how to reverse the damage. Learn more at www.theasinger.com.

from： http://www.thedailybeast.com/anti-aging-pill-new-study-on-ta-65-sparks-controversy

Finiti from Jeunesse Global 

Main Ingredients :TA-65 MD

Resveratrol, a red wine polyphenol, protects spinal cord from ischemia-reperfusion injury.

Kiziltepe U, et al. J Vasc Surg. 2004.

Show full citation

Abstract

OBJECTIVE: The cardioprotective effect of red wine has been attributed to resveratrol. The resveratrol-induced protection against ischemia-reperfusion (I/R) injury has been documented in heart, kidney, and brain. Resveratrol scavenges free O(2) radicals and upregulates nitric oxide (NO). However, the presence of resveratrol-induced spinal cord protection against I/R injury has not been reported in the literature. The objective of this study was to evaluate the effects of resveratrol on neurologic functions, histopathologic changes, and NO metabolism following temporary spinal cord ischemia (SCI) in rabbits. Material and methods SCI was induced with occlusion of the infrarenal aorta in rabbits. In addition to the sham group (group S, n = 7), group C (n = 7) received vehicle 30 minutes before ischemia. Group R1 (n = 7) and R10 (n = 7) received 1 mg/kg and 10 mg/kg resveratrol instead of vehicle, respectively. Blood samples were taken to obtain nitrite/nitrate levels during the surgical procedure. After neurologic evaluation at the 48th hour of reperfusion, lumbar spinal cords were removed for histopathologic examination and malondialdehyde measurement as a marker of oxidative stress.

RESULTS: Five animals in group C had paraplegia while 5 in group R10 had normal neurologic functions. The average Tarlov score of group R10 was significantly higher than that the score of group C (4.1 +/- 1.2, vs 1.2 +/- 2.2; P =.014). Histopathologic examination revealed higher neuronal viability index in group R10 compared with that of group C (0.82 +/- 0.24 vs. 0.46 +/- 0.34; P =.018). Nitrite/nitrate levels decreased in group C (from 357 +/- 20.15 micromol/L to 281 +/- 47.9 micromol/L; P <.01) whereas they increased both in group R1 and group R10 (from 287+/-28 micromol/L to 310 +/- 33.9 micromol/L and from 296 +/- 106 micromol/L to 339 +/- 87 micromol/L, respectively) during SCI. Malondialdehyde levels of group R10 was lower than those of group C (55 +/- 12.9 nmol/mg protein vs 83.9 +/- 15.1 nmol/mg protein; P =.001, respectively).

CONCLUSIONS: In this model of SCI, resveratrol decreased oxidative stress, increased NO release, and protected spinal cord from I/R injury. Resveratrol-induced neuroprotection is probably mediated by its antioxidant and NO promoting properties. Before considering the clinical use of this natural antioxidant, further research is warranted about its mechanism of effects, timing, and optimum dose.

CLINICAL RELEVANCE: Paraplegia that results from spinal cord ischemia is a catastrophic complication of thoracic and thoracoabdominal aorta surgical procedures. Despite several surgical modifications and pharmacologic approaches, paraplegia has not been totally eliminated. On clinical grounds, the efficiency of currently used pharmacologic agents to prevent spinal cord injury during thoracic and thoracoabdominal aorta surgery is very limited and their benefit is controversial. Preischemic infusion of resveratrol protects the spinal cord from ischemia reperfusion injury in rabbits. Following clarification of the underlying protective mechanism, optimal dose, and timing, resveratrol may used in humans as an adjunct to eliminate this catastrophic complication.

PMID

 15218474 [PubMed - indexed for MEDLINE]

https://www.ncbi.nlm.nih.gov/m/pubmed/15218474/

Dr Vincent Giampapa was nominated for a 2014 Nobel Prize in the area of Stem Cell Research.

Dr Vincent Giampapa was nominated for a 2014 Nobel Prize in the area of Stem Cell Research.

This video explains in laymen's terms on what he has developed to help combat aging in 3 main areas:

• 1. Stem Cell Maintenance 
• 2. DNA Repair 
• 3. Inhibit Free Radical (that damage the DNA)
• 4. Telomere protection (our aging clock)

When combined with the Reserve Product and the stem cell repair and protection skincare line (Luminesce),is a TRUE FIRST in directing the LATEST RESEARCH towards these systems at the cellular level.

We are able to see a dramatic improvement not only in how we feel but how our skin as aging not only from the outside in, but the inside out.


What do we have that no one else does? We have a series of products that work at the cellular level both internally and externally. When used together... results are dramatic!

THESE ARE NOT VITAMIN/MINERAL SUPPLEMENTS - IT'S A WHOLE NEW CATEGORY CALLED NUTRIGENETICS.

This focus on working at the ORIGIN on the effect of aging, not the EFFECTS of aging.

How to slow the shortening of your telomeres:

• 1. The right combination of antioxidants
• 2. Limiting your homocysteine levels
• 3. Keep your cortisol levels down (blood sugar and stress)
• 4. Include a telomorase "activator" -- (finit)

For the skin - Luminesce -repairs DNA, includes growth factors that works with the DNA complex

Inside out - Nutrigene which has been tested for a number of years...

Come to check Jeunesse products:  http://luckyhome.jeunesseglobal.com
You can choose buy retail price or you can choose by member price to save around 35%.
Membership fee is $29.95USD/year.

Sign up as member is very easy and sample. Just click the Join now and follow the steps to sign up as member. You can order special package right away or you can just register a member first.