Tuesday, November 28, 2017

GABA-Boosting Brain Foods


While there are several drugs that help to boost GABA, there are also some natural ways to get the peace and calm your brain needs. Finding natural solutions have a few benefits. First, they’re not addictive like many of the prescription medications. Also, they won’t leave you feeling groggy, so you’ll still be able to be productive at work and at home.

You know that feeling you get in the middle of a frantic workday with 3 deadlines approaching while your kids keep texting you about dinner? If we were to take a look inside your brain, the chemicals that act like your car’s accelerator pedal – dopamine, adrenaline, norepinephrine – are surging. And GABA, the chemical that acts like your car’s brakes, is in short supply.
http://www.doctoroz.com/episode/biggest-scams-threatening-your-health

Here are 5 ways to get the GABA your brain is craving:
  1. Swap your afternoon coffee for a cup of oolong tea. When we feel overworked and worn out, coffee is a natural go-to. But its high levels of caffeine send the activating brain chemical dopamine soaring. The tradeoff for short-term productivity is a jittery feeling and insomnia hours later. Try oolong tea instead. It contains GABA, and sipping it may provide you with the break your brain and body needs. The break you’ll get may provide you with the stamina to get everything done without feeling worn out.
  2. Swap the candy bar for cherry tomatoes and hummus. The high levels of fat in that candy bar are not only bad for your waistline, it’s bad for your brain! High levels of unhealthy fat also increase dopamine levels. But cherry tomatoes are rich in GABA, and the olive oil in hummus helps to balance your omega-3 versus omega-6 ratio. This ratio can help balance all of your brain chemicals over the long-term which will leave you feeling peaceful and happy.
  3. Swap the soda for a glass of kefir, a probiotic drink. Soda is not only associated with obesity; a new study showed an association with soda (and diet soda) and depression. Kefir contains GABA, and the carbohydrates boost serotonin – your other main feel-good, peaceful brain chemical. Talk about a double whammy!
  4. Swap orange chicken and fried rice for grilled shrimp and brown rice. The high fat in orange chicken and fried rice flood your brain with dopamine which can even set you up for food addiction. But the shrimp contains a healthy dose of GABA, and the high-fiber brown rice gives you nice, healthy release of serotonin.
  5. Ditch the TV and downward dog your way to bliss. At the end of a long day, sitting on the couch and mindlessly watching hours of TV may be the easy fix. But if we really want to get the peace and happiness we’re really craving, we may have to get a little more creative. Buy yourself a zafu – a round meditation pillow. When you get home, set the kitchen timer for 10 minutes and practice meditation. Start increasing that time by 1 minute each day until you can sit for 30 minutes. Or, find a great yoga class, and go with friends. Your body and your brain will thank you!

Sunday, July 30, 2017

T.A. Sciences receives US patent for TA-65 to tackle aging process

Telomerase Activation Sciences, Inc. (T.A. Sciences) today announced the issuance of U.S. Patent No. 7,846,904 to the Geron Corporation. The patent covers the use of certain compounds to upregulate telomerase expression in cells.
T.A. Sciences has exclusive worldwide rights to technology under this patent for nutraceutical and cosmetic applications.
"This foundational patent is a validation of the millions of dollars and more than 8 years of effort we have invested to bring TA-65, the world's first telomerase activator, to market," stated Noel Thomas Patton, Chairman of T.A. Sciences. "This significantly adds to the proprietary rights that Geron has built around its already strong portfolio of U.S. and foreign patents that will allow vigorous defense against infringers. T.A. Sciences has provided TA-65 to hundreds of clients for nearly four years with significant demonstrated anti-aging and immune boosting benefits."
"Cells are the building blocks for all tissues in the human body and cell division plays a critical role in the normal growth, maintenance and repair of human tissue. We and our collaborators have shown that telomeres, located at the ends of chromosomes, are key genetic elements involved in the regulation of the cellular aging process. Thus, this shortening of the telomeres effectively serves as a molecular 'clock' for cellular aging. We and others have shown that when the enzyme telomerase is introduced into normal cells, it can restore telomere length - reset the 'clock' - thereby increasing the functional lifespan of the cells. Importantly, it does this without altering the cells' biology or causing them to become cancerous...Controlled activation of telomerase in normal cells can restore telomere length or slow the rate of loss, improve functional capacity and increase the proliferative lifespan of cells," Source:Geron 2009 Annual Report.
The awarding of the patent follows the first published peer reviewed scientific paper on TA-65: "A Natural Product Telomerase Activator..." which appeared in the journal Rejuvenation Research in Sept 2010. This study focused on two key results that were observed in T.A. Sciences' clients who had taken TA-65 for a 12 month period. TA-65 led to a reduction in the percentage of short telomeres in immune cells and also showed a significant restoration of the immune system back to a more youthful profile.  A number of other significant improvements were observed in various biomarkers which show decline with age and these will be reported in a subsequent paper. Importantly, there were no reported side effects.
Two earlier papers help to confirm these benefits.  The first paper (Fauce et al., 2008) describes the chemical structure of a small molecule telomerase activator discovered at the Geron Corporation in collaboration with the Hong Kong University of Science and Technology. They were able to demonstrate that activating telomerase with a telomerase activator slowed the rate of telomere loss, increased replicative capacity (without immortalization or signs of tumor transformation), restored cytokine and chemokine response of cytotoxic CD8 cells exposed to specific antigens. The other, a 2005 Double Blind, Placebo Controlled  Human Trial also demonstrated improvements in immune function, vision, sexual function, and skin elasticity.
Telomere Biology has become the most relevant topic in anti-aging research. In a study released on November 28th 2010, in the online journal Nature, a team of researchers at Harvard Medical School reported on the first reversal of the aging process in a mammal. By reactivating telomerase, they rejuvenated worn out organs in mice that were the equivalent biological age to 80 year old humans. This along with the 2009 Nobel Prize in Medicine being awarded for the discovery of telomerase and the publication of over 8,000 other scientific articles about telomere biology confirm the emergence of a major scientific platform.  
All of this emphasizes the importance of short telomeres in the aging process and has ushered in a new approach to how we tackle aging in humans. That approach is to stop telomere shortening by activating telomerase. And now TA-65 is the first and only product available which has been shown to effectively activate this enzyme.

FINITI :
main Ingredients: TA-65 MD


Thursday, June 15, 2017

Anti-Aging Pill: New Study on TA-65 Sparks Controversy

A major new study claims the pricey supplement TA-65 may turn back the clock, all the way down to our DNA—but many scientists are brushing it off as snake oil. Thea Singer investigates.


In an era of seemingly magical technology, the notion that scientists could develop a pill that might slow the aging process doesn’t seem that far-fetched. After all, we can now perform face transplants. We can control machines with our minds. How far could we be from producing a treatment that rejuvenates our cells?
According to some researchers: We’re already there. For several years now, a handful of supplement and biotechnology companies claim to be hot on the trail of the miracle anti-aging formula humankind has long sought—and one product has already hit the market.
Made from a Chinese herb called Astragalus membranaceus, the “nutraceutical” is referred to by the equally futuristic and drab-sounding name of TA-65. And it claims to reverse the clock at a cellular level, all the way down to our DNA. The capsule ranges from $1,200 to $4,000 for a six-month supply, depending on the dose.
T.A. Sciences, a New York supplement company, manufactures the pill, andemployees swear by it. “My immune system is younger, my eyesight is improved, the glucose and cholesterol levels in my blood have gone down, and I have increased cognitive function,” says Noel Patton, the 65-year-old founder and CEO of the company. He’s been taking it for four years.
The mainstream scientific community has, for the most part, viewed the supplement extremely skeptically. But a new study, backed up by a few scientific heavyweights, suggests that it may just work. The paper appears today in Aging Cell—though the journal was so eager to get the word out that it posted it online in late March, even before the acknowledgments were complete. My quest to investigate the study, however, led to a tangled web of believers and nonbelievers, and a raging controversy in the field of anti-aging research. Is T.A. Sciences marketing snake oil, or a ticket to prolonged youth?
To understand the paper’s implications, it helps to understand how TA-65 claims to work. The pill purports to restore our telomeres—the protective caps at the end of our DNA. Like the plastic tips at the end of shoelaces, these caps, with time, illness, and stress, eventually wear down, leading to physical signs of aging. Scientists now view telomere length as an overall marker of biological aging. For example, babies have longer telomeres than adults—or, as Patton put it to me, in a kind of cognitive foot-in-mouth, “babies are always born young.”
My quest to investigate the study led to a tangled web of believers and nonbelievers—and a raging controversy in the field of anti-aging research.
Over the past few decades, the study of telomeres has risen to become a white-hot area of very legitimate scientific research. In 2009, a team of scientists won the Nobel Prize in Physiology or Medicine for their breakthrough research into how telomeres work. Each time a cell divides, its telomeres get progressively shorter. When telomeres get so short that a cell can’t function, the cell either enters a resting state or dies.
But there’s a rejuvenative source for these worn-out cells. And that’s what T.A. Sciences aims to tap into—along with a California company called Geron Corp., a biotech dedicated to developing drugs to treat cancer and chronic degenerative diseases, which licensed TA-65 to Patton as a neutraceutical while keeping its own extract from the Chinese plant, called TAT2, to develop as a drug.
That life-giving source is the enzyme telomerase, which can actually lengthen telomeres. TA-65, the new study claims, is a “telomerase activator”—that is, it turns on telomerase in cells. Studies suggest that telomerase can also beactivated naturally, through exercise, meditation, and other healthy lifestyle changes. But taking a pill is, of course, easier.
The lead author of the new paper is Maria Blasco, a prolific scientist who heads the Telomeres and Telomerase Group at the Spanish National Cancer Research Centre. In the paper, Blasco reports that in genetically engineered mice, TA-65 rescued cells in jeopardy and improved health without increasing cancer incidence—a risk when cells can divide for longer periods of time.
In her study, a group of middle-aged and old mice ate food spiked with TA-65, while another group, the controls, ate plain food. (The age of the mice was intentional: TA-65 is marketed to people in their forties and up.) After three months, the scientists took blood samples, and measured the lengths of the telomeres of both groups. And sure enough: Mice that ate the TA-65 had a lower percentage of “very short telomeres.” They also displayed lower insulin levels, hair regrowth, and increased skin plumping. Blasco takes these changes as evidence that TA-65 works by “turning on” telomerase.
But the changes didn’t last, and overall longevity didn’t change. Nor did average telomere length of the treated mice—a measure that countless previous studies have deemed the more important measure, as it’s been proven to correlate with everything from reduced disease risk to lower mortality.
This last detail concerns Carol Greider, who, along with Elizabeth Blackburn and Jack Szostak, won the Nobel for the discovery of telomerase and how telomeres protect chromosomes. “There are a number of questions about the actual claims just in terms of: Is TA-65 really doing what they think it’s doing?” says Greider about the new paper.
She reflects, too, on an earlier study, in the journal Rejuvenation Research, showing similar results in humans (that is, T.A. Sciences customers) taking TA-65, along with vitamin supplements: The subjects’ mean telomere length did not increase, but their percentage of very short telomeres appeared to decrease. “I haven’t seen yet that they actually change telomere length, which is the clear real indicator,” adds Greider.
When I first contacted the Nobel laureate, she sent me a paper reporting that if taken in pill form, Geron’s drug-in-progress from the Chinese herb (TAT2) couldn’t even get to the body’s cells to make a difference. “This particular drug wouldn’t be one that you would give orally,” says Greider. “There would need to be some sort of chemical modification… for it to actually be useful.” No one connected to TA-65 will say if the supplement and TAT2 are chemically the same—“it’s a trade secret,” says Patton. But he assured me that results from studies on TAT2 are “definitely applicable” to TA-65.
Calvin Harley, a co-author on all three papers and chief scientific officer of Telome Health Inc., a new telomere-diagnostics company based in Northern California, acknowledges that concentrations of the active anti-aging ingredient may be low. But he says the pill can still activate telomerase in human cells in the lab—and the low potency helps to reduce safety concerns.
But Greider and other scientists point out both Blasco and Harley’s vested interest in the pill. Harley, 58, is a pioneer in telomere research, and a rigorous scientist. But he’s also an inventor of TA-65, and an adviser to both Geron and T.A. Sciences.
“I hate to say it, but I really think that money corrupts,” says noted cellular aging researcher Judith Campisi, pointing to the timing of the paper’s release—which happens to coincide with the launch of Blasco’s new company, Life Lengths, which measures people’s telomeres. Campisi, based at California’s Buck Institute for Research on Aging, has another concern as well: Telomerase doesn’t cause cancer, but cancer cells are telomerase-rich—it’s what enables them to divide indefinitely. Blasco’s new paper reports that the treated mice did show an increase of liver cancer, though those levels “did not reach statistical significance.”
Ultimately, the paper—and the supplement—may prove to be an important step in leading to a formula that, in fact, allows us to live longer, and with a higher quality of life. But for now, as Campisi points out about the splashy new study: “It really reads like an apology for a company.”
Thea Singer has written about health and science for more than three decades. Based in Boston, she is the author of Stress Less (Hudson Street Press/Penguin Group, USA), which reveals how stress ages us down to our DNA, and how to reverse the damage. Learn more at www.theasinger.com.


from: http://www.thedailybeast.com/anti-aging-pill-new-study-on-ta-65-sparks-controversy

Finiti from Jeunesse Global 

Main Ingredients :TA-65 MD


Monday, June 5, 2017

Resveratrol, a red wine polyphenol, protects spinal cord from ischemia-reperfusion injury.

Kiziltepe U, et al. J Vasc Surg. 2004.

Abstract

OBJECTIVE: The cardioprotective effect of red wine has been attributed to resveratrol. The resveratrol-induced protection against ischemia-reperfusion (I/R) injury has been documented in heart, kidney, and brain. Resveratrol scavenges free O(2) radicals and upregulates nitric oxide (NO). However, the presence of resveratrol-induced spinal cord protection against I/R injury has not been reported in the literature. The objective of this study was to evaluate the effects of resveratrol on neurologic functions, histopathologic changes, and NO metabolism following temporary spinal cord ischemia (SCI) in rabbits. Material and methods SCI was induced with occlusion of the infrarenal aorta in rabbits. In addition to the sham group (group S, n = 7), group C (n = 7) received vehicle 30 minutes before ischemia. Group R1 (n = 7) and R10 (n = 7) received 1 mg/kg and 10 mg/kg resveratrol instead of vehicle, respectively. Blood samples were taken to obtain nitrite/nitrate levels during the surgical procedure. After neurologic evaluation at the 48th hour of reperfusion, lumbar spinal cords were removed for histopathologic examination and malondialdehyde measurement as a marker of oxidative stress.
RESULTS: Five animals in group C had paraplegia while 5 in group R10 had normal neurologic functions. The average Tarlov score of group R10 was significantly higher than that the score of group C (4.1 +/- 1.2, vs 1.2 +/- 2.2; P =.014). Histopathologic examination revealed higher neuronal viability index in group R10 compared with that of group C (0.82 +/- 0.24 vs. 0.46 +/- 0.34; P =.018). Nitrite/nitrate levels decreased in group C (from 357 +/- 20.15 micromol/L to 281 +/- 47.9 micromol/L; P <.01) whereas they increased both in group R1 and group R10 (from 287+/-28 micromol/L to 310 +/- 33.9 micromol/L and from 296 +/- 106 micromol/L to 339 +/- 87 micromol/L, respectively) during SCI. Malondialdehyde levels of group R10 was lower than those of group C (55 +/- 12.9 nmol/mg protein vs 83.9 +/- 15.1 nmol/mg protein; P =.001, respectively).
CONCLUSIONS: In this model of SCI, resveratrol decreased oxidative stress, increased NO release, and protected spinal cord from I/R injury. Resveratrol-induced neuroprotection is probably mediated by its antioxidant and NO promoting properties. Before considering the clinical use of this natural antioxidant, further research is warranted about its mechanism of effects, timing, and optimum dose.
CLINICAL RELEVANCE: Paraplegia that results from spinal cord ischemia is a catastrophic complication of thoracic and thoracoabdominal aorta surgical procedures. Despite several surgical modifications and pharmacologic approaches, paraplegia has not been totally eliminated. On clinical grounds, the efficiency of currently used pharmacologic agents to prevent spinal cord injury during thoracic and thoracoabdominal aorta surgery is very limited and their benefit is controversial. Preischemic infusion of resveratrol protects the spinal cord from ischemia reperfusion injury in rabbits. Following clarification of the underlying protective mechanism, optimal dose, and timing, resveratrol may used in humans as an adjunct to eliminate this catastrophic complication.

PMID

 15218474 [PubMed - indexed for MEDLINE]


https://www.ncbi.nlm.nih.gov/m/pubmed/15218474/